5th DNA Polymerases meeting
23 - 26 September 2018, Leiden, The Netherlands

The finalized program can be downloaded here and is also listed below in a short version.

For poster presenters: 

For the “poster pitch” sessions on Monday, please use this template to prepare one (and only one) slide and send it to the meeting secretariat before Friday 21 September 2018.

 

Posters can be hung on Sunday 23 September in the afternoon and taken down again on Wednesday. Poster boards are 125 x 100 cm (h x w), so it is best to print your poster in portrait style. Push pins or Velcro will be provided for hanging. 


Program

 Sunday 23 September 2018


14:00 - 15:00  Registration open 
15:00  Opening
15:05 - 15:45 Keynote Lecture: Serena Nik-Zainal: Recent advances in DNA replication/repair on mutational signatures
15:45 - 16:10 Ruben van Boxtel: Dissecting mutation patters in human stem cells to study processes that cause cancer
16:10 - 16:25 Anton Gartner: Using massive Caenorhabditis elegans whole-genome sequencing to investigate mutational signatures of DNA repair deficiency and carcinogen exposure, important roles of translesion synthesis
16:25 - 16:40 Robin van Schendel: Okazaki fragment deposition dictates deletion mutagenesis at persistant replication fork barriers
16:40 - 17:05 Coffee/tea break
17:05 - 17:30 Tom Kunkel: Studies of eukaryotic DNA replication fidelity
17:30 - 17:55 Peter Burgers: The control of eukaryotic mutagenesis by Rev1 and DNA polymerase zeta
17:55 - 18:10 Michal Dmowski: CMGE complex and the stability of repetitive DNA sequences in Yeasts
18:10 - 18:25 Vincent Pagès: DNA polymerases vs. exonucleases during replication of a damage DNA
18:25 - 18:40 Penny Beuning: Roles of active site and distal residues in Y-family polymerase activity
         
      Walk to hotel
19:30              Dinner 
 


Monday 24 September 2018

09:00   'Replicative DNA polymerases and the replisome'
09:00 - 09:40 Keynote Lecture: Mike O'Donnell: Structure and function of the eukaryotic DNA replication machinery
09:40 - 10:05 Meindert Lamers:  Structural features of high fidelity DNA replication
10:05 - 10:30 Tahir Tahirov: Elaborated action of the human primosome
10:30 - 11:00 Coffee/tea break
11:00 - 11:25 Alessandro Costa: Cryo-EM studies of helicase-polymerase coupling in the eukaryotic replisome
11:25 - 11:50 Antoine van Oijen: Single-molecule studies of DNA replication: the plasticity of the replisome
11:50 - 12:05 Lisanne Spenkelink: Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis by pol ε reveals dynamic interaction between MTC and the replisome
12:05 - 12:40 Poster Pitch Presentations (1 - 30)
12:40 - 13:45 Lunch
13:45 - 14:10 Sam Wilson: Mechanisms of fast and slow DNA polymerases
14:10 - 14:35 Zucai Suo: New insights into mechanisms of DNA polymerization
14:35 - 14:50 Deepak Nair: Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction catalyzed by DNA polymerases
14:50 - 15:20 Poster Pitch Presentations (31 - 55)
15:30               Excursion
17:00               Reception Town Hall
18:30 - 22:00  Poster viewing session and dinner

 

Tuesday 25 September 2018


09:00  'Non-canonical DNA replication'
09:00 - 09:40 Keynote Lecture: Wei Yang: Seeing is believing: juggling DNA replication, TLS and end joning
09:40 - 10:05 Wolf-Dietrich Heyer: Saccharomyces cerevisiae DNA polymerase gamma functions in homology-directed DNA repair in cooperation with DNA polymerase δ
10:05 - 10:20 Giovanni Maga: Tales of a hybrid genome: when RNA processing meets DNA stability
10:20 - 10:35 Ross Chapman: 53BP1 cooperation with the Rev7-Shieldin complex underpins DNA structure-specific NHEJ
10:35 - 11:00 Coffee/tea break
11:00 - 11:25 Richard Pomerantz: Identification of small molecule inhibitors of PolQ as anti-cancer drug leads
11:25 - 11:50 Dale Ramsden: Polymerases that bridge broken chromosomes
11:50 - 12:15 Jean-Sébastien Hoffmann: Adaptive mechanisms to replicative stress: implication of DNA polymerase Θ
12:15 - 12:30 Noritaka Adachi: Role of human DNA polymerase Θ at double-strand breaks
12:30 - 12:45 Marc DelaRue: Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase Θ mutants for the generation of aptamer libraries
12:45 - 14:15 Lunch
14:15 - 14:40 Luis Blanco: A two-gear priming mechanism by human PrimPol
14:40 - 15:05 Julian Sale: Polymerase deployment during the replication of structured DNA
15:05 - 15:30 Aidan Doherty: Uncovering the roles of Primase-Polymerases in DNA gap repair
15:30 - 15:45 Sjoerd Wanrooij: PrimPol is required for replication reinitiation after mtDNA damage
15:45 - 16:00 Modesto Redrejo-Rodríguez: Primer-free DNA replication by a new clade of family B DNA polymerases
16:30               Excursion (incl. drinks and snacks)
19:30               Gala dinner


  

Wednesday 26 September 2018

09:00   'DNA polymerases and disease'
09:00 - 09:40 Key Note Lecture: William Copeland: Mitochondrial DNA mutagenesis in POLG disorders
09:40 - 10:05 David Church: Replicative polymerase mutations as cancer biomarkers
10:05 - 10:30 Polina Shcherbakova: DNA polymerase ε mutations in human cancers: consequences and mechanisms
10:30 - 10:45 Vimal Parkash: Structural consequence of the most frequent recurring cancer associated substitution in DNA polymerase ε
10:45 - 11:15 Coffee/tea break
11:15 - 11:40 Rick Wood: DNA polymerase zeta and cancer
11:40 - 12:05 Mitch McVey: Coordination of DNA damage bypass by REV1
12:05 - 12:30 Patricia Kannouche: Pol zeta as a critical factor for genome stability in heterochromatin domains
12:30 - 12:45 Simone Sabbioneda: Phosphorylation regulates human pol eta stability and damage bypass throughout the cell cycle
12:45 - 13:00 Anastasia Tsaalbi-Shtylik: Pathological phenotypes induced by unreplicated DNA lesions
13:00 - 14:35 Lunch
14:35 - 14:50 Dmitry Korzhnev: Protein interactions in Rev1/Pol zeta-dependent TLS: from mechanisms to drug design
14:50 - 15:05 Sarah Henrikus: Reactive oxygen species promote DNA polymerase IV activity in Escherichia coli
15:05 - 15:20 Ildiko Unk: Yeast Polymerase eta is a new candidate to perform translesion RNA synthesis
15:20 - 15:40 Coffee/tea break
15:40 - 16:05 Andreas Marx: Artificial DNA polymerase systems
16:05 - 16:20 Andrew Gardner (NEB): RADAR-seq: a RAre DAmage and Repair sequencing method for detecting and locating physiological levels of DNA damage and in vivo DNA replication on a genome-wide scale
16:20 - 16:40 Marcel Tijsterman & Niels de Wind: On the 6th Polymerase meeting and closure
                    Walk to Restaurant
17:30 - 22:00 Closing drinks, dinner and party


Thursday 27 September 2018 

Breakfast and departure